There are numerous types of metahumans - and while mutant ninja turtles may not be commonplace in the world of Metaheroes, it's generally accepted that physical differences are unavoidable for metahumans who do have them. There won't be any extra side-eyeing from the general public, unless clearly non-human people use abilities that normal humans wouldn't have in public.

IE, Donatello walking around the street won't get any strife. Donatello using his Ninpo would.